New York University;University Of Southern California
发明人:
申请号：
EP13749783.0
公开号：
EP2814821B1
申请日:
2013.02.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to oligooxopiperazines that mimic helix &alpha；B of the C-terminal transactivation domain of HIF-1&alpha；. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1&alpha； with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
