R0 R 1 R 1 ' R9' R10' R 11 ' R ii 0 II N—S—Y—R 4 (I) 0 R 9 R 8 0 R10 R2' (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIP0 I PCT ill 1111u°11101VIIIVIIIVIIIolo oloinomonimmom oimIE (10) International Publication Number WO 2018/175474 Al (51) International Patent Classification: (74) Agent: REARICK, John P. et al.； Choate, Hall & Ste- CO7D 487/04 (2006.01) CO7D 519/00 (2006.01) wart LLP, Two International Place, Boston, Massachusetts A61K 31/407 (2006.01) A61P 7/00 (2006.01) 02110 (US). C (21) International Application Number: PCT/US2018/023405 (22) International Filing Date: 20 March 2018 (20.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/473,751 20 March 2017 (20.03.2017) US (71) Applicant: FORMA THERAPEUTICS, INC. [US/US]； 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). (72) Inventors: ERICSSON, Anna； c/o Forma Therapeutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massa- chusetts 02472 (US). GREEN, Neal； c/o Forma Thera- peutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). GUSTAFSON, Gary； c/o For- ma Therapeutics, Inc., 500 Arsenal Street, Suite 100, Wa- tertown, Massachusetts 02472 (US). HAN, Bingsong； c/ o Forma Therapeutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). LANCIA, JR., David R.； c/o Forma Therapeutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). MITCHELL, Lorna； c/o Forma Therapeutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). RICHARD, David； c/o Forma Therapeutics, Inc., 500 Arsenal Street, Suite 100, Watertown, Massachusetts 02472 (US). SHELEKHIN, Tatiana； c/o Forma Therapeu- tics, Inc., 500 Arsenal Street, Suite 100, Watertown, Mass- achusetts 02472 (US). SMITH, Chase C.； c/o Form
