The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Wang, Qiong J.,Hanada, Kenichi,Yang, James C.
申请号：
AU2009282886
公开号：
AU2009282886B2
申请日:
2009.08.20
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The invention provids an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.
