DISPOSITIF DE LIBERATION DE DROGUE REVETU D'UNE BICOUCHE POLYMERE COMPORTANT UN INHIBITEUR DE LA CIBLE MAMMIFERE DE RAPAMYCINE INCORPORE DANS LA PREMIERE COUCHE DU REVETEMENT POLYMERE
FALOTICO, ROBERT,KOPIA, GREGORY A.,LLANOS, GERARD H.,SIEKIERKA, JOHN
申请号：
CA2504582
公开号：
CA2504582C
申请日:
2005.04.21
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
There is described herein a drug delivery device. The device comprises anintraluminal medical device；a biocompatible, nonerodible polymeric coatingaffixedto the intraluminal medical device, the polymeric coating including first andsecondlayers； anda therapeutic dosage of an inhibitor of the mammalian Target ofRapamycin incorporated into the first layer of the polymeric coating for atreatmentof intimal hyperplasia. The first and second layers of the polymeric coatingareconfigured to release the inhibitor of the mammalian Target of Rapamycin intothetissue around the intraluminal medical device for a period ranging from aboutthree days to about fifty-six days, the second layer of the polymeric coatingbeingconfigured substantially as a diffusion barrier for controlling the releaserate of theinhibitor of the mammalian Target of Rapamycin, the first layer having athicknessin the range from about 8 microns to about 12 microns and the second layerhaving a thickness in the range from about 1 micron to about 2 microns,whereinthe inhibitor of the mammalian Target of Rapamycin comprises an antagonist ofacatalytic activity of a phosphoinositide (PI) -3 kinase.
