親水性生理活性物質含有微粒子の製造方法
- 专利权人:
- 東レ株式会社
- 发明人:
- 小屋松 祐一,柿澤 資訓,平野 泰亮
- 申请号：
- JP2010002765
- 公开号：
- JP5560719B2
- 申请日:
- 2010.01.08
- 申请国别(地区):
- JP
- 年份:
- 2014
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide a method for producing a fine particle of a narrow particle size distribution containing a hydrophilic physiologically active substance.
SOLUTION: The method for producing a fine particle containing a hydrophilic physiologically active substance comprises (a) a step of forming a reversed phase emulsion by mixing an aqueous solvent having dissolved therein a hydrophilic physiologically active substance with a water-immiscible organic solvent having dissolved therein an amphiphatic polymer composed of a hydrophobic segment of a poly(hydroxy acid) and a hydrophilic segment of a polysaccharide or polyethylene glycol, (b) a step of obtaining solid matter containing the hydrophilic physiologically active substance by removing the solvents from the reversed phase emulsion, (c) a step of dispersing the solid matter containing the hydrophilic physiologically active substance in a solvent A in which the hydrophobic segment of the amphiphatic polymer is soluble while the hydrophilic segment of the amphiphatic polymer is insoluble, and (d) a step of adding the solid matter containing the dispersion of the hydrophilic physiologically active substance obtained in the step (c) to a solvent B which has dissolved therein a surface-modifier and is miscible with the solvent A and in which the hydrophobic segment of the amphiphatic polymer is insoluble.
COPYRIGHT: (C)2011,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
