The present invention discloses an invention comprising a treatment regime for chronic sinusitis. The regime includes destruction of biofilm and prevention of its formation achieved by a series of applications of compositions that comprise phenol, phenolic, or polyphenolic compounds as a contact/topical application to sinus membranes/tissue. The compositions may comprise phenolic or other compounds sourced naturally. Over-the-counter therapeutic use or in-office application or therapy are all possible implementations.
