An apparatus configured to remove one or more substances from the Blood,The Apparatus comprises: a primary filter (30) semipermeable Membrane comprising a First 5 (36) that separates Blood compartment (32) of a cargo compartment of dialysate (34) a Blood Circuit configured to move Blood through the blood compartment (32) of the primary filter (30) using a Blood pump (20),In the blood Circuit comprises a line of Blood (10112) configured to move blood from the blood pump (20) to the blood compartment (32) of the primary filter (30), a non-invasive Pressure sensor (16) arranged around a SurfaceOutside the bloodline (10, 112), The Pressure sensor is configured to detect the pressure non-invasive blood pressure (line 10,112) and a Control Unit (17) operationally connected to the Pressure sensor (16) and non-invasive control elements of the blood Cycle,The Control Unit (17) is configured to control a blood pressure value of the Pressure sensor Circuit using the non-invasiveCharacterized in that the Control unit is configured to operate the control elements of the circuit depending on the value of blood pressure Blood Circuit controlledThe Control unit is configured to act once the Absolute value of blood pressure of the circuit or the pressure gradient of the circuit is not in bloodA Predetermined range of values, in which the action of the Control Unit includes providing an indication of alarm and alter the flow of the blood pump (20),Including the stage of alteration to disable the blood pump (20) when the pressure of the blood Circuit controlled Blood indicates that the circuit is coupled to the Pressure sensor invAsivo (16).Un aparato configurado para eliminar una o más sustancias de la sangre, en el que el aparato comprende: un filtro primario (30) que comprende una primera membrana semipermeable 5 (36) que separa un compartimento de sangre (32) de un compartimento de carga de dialisato (34) un circuito sanguíneo configurado para mover sangre a través del compartimen
