Biopsy systems, as well as related methods and components, are disclosed. In some embodiments, a biopsy system can include a biopsy gun and a spacer. The biopsy gun can include a housing having a proximal end and a distal end, and a biopsy needle having a proximal end and a distal end. A lumen can extend partially through the housing, and can have a distal end that is defined by the distal end of the housing. A lumen also can extend through the spacer, which can be associated with the distal end of the housing. The biopsy needle can have a first position in which its distal end is disposed within the lumen of the housing or the lumen of the spacer, and a second position in which its distal end is disposed external to the lumen of the housing and the lumen of the spacer.
