A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle 5 includes the steps of: identifying a drug desired to be delivered； identifying a volume of the drug desired to be delivered； establishing a reservoir diameter for the at least one drug reservoir； establishing a nozzle diameter for the at least one injection nozzle； identifying a tissue model for delivery of the drug； identifying a penetration depth in the tissue model for the delivery of the drug； and injecting the drug into the 10 tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth. 27/07/06,15862 speci,2 72 3/10 74 2 -52 -442 40-3
