BUCKMAN, BRAD OWEN,YUAN, SHENDONG,EMAYAN, KUMARASWAMY,ADLER, MARC,NICHOLAS, JOHN BEAMOND (DECEASED),MA, JINGYUAN
申请号：
CA3067063
公开号：
CA3067063A1
申请日:
2018.06.19
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Small molecule calpain modulator compositions and pharmaceutical compositions can be prepared and used as therapeutic agents. Exemplary compositions include non-macrocyclic a-keto amide derivatives. The therarapeutic agents can be used for treating fibrotic disease or a resulting secondary disease state or condition. The small molecules can competitively bind with calpastatin and/or inhibit calpain through contact with CAPN1, CAPN2, and/or CAPN9 enzymes.
