A system for treating multiple tissue sites of a patient includes a first dressing filler adapted to be positioned at a first of the tissue sites. A second dressing filler is adapted to be positioned at a second of the tissue sites. A bridge manifold is positioned between the first tissue site and the second tissue site to provide fluid communication between the first and the second tissue site. A reduced pressure source is fluidly connected to at least one of the bridge manifold, the first tissue site, and the second tissue site. A valve is operably associated with one of the first and the second tissue sites to allow fluid to flow from the one of the first and the second tissue sites, but precluding flow towards the one of the first and the second tissue sites.