Steven L. McKnight,Andew A. Pieper,Joseph M. Ready,Jef K. De Brabander,Jeffrey M. Zigman
申请号：
US14339772
公开号：
US09162980B2
申请日:
2014.07.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinsons disease, Alzheimers disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntingtons disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
