Wolfgang M. Franz,Hans Theiss,Marc-Michael Zaruba,Stefan Brunner
申请号：
US12410209
公开号：
US08455435B2
申请日:
2009.03.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to uses and methods of parathyroid hormone (PTH), preferably PTH (1-34), and/or parathyroid hormone-related peptide (PTHrP), preferably PTHrP (1-34), for recruiting stem cells into tissue suffering from ischemia, wherein said stem cells are preferably capable of repairing and/or regenerating said tissue suffering from ischemia. Also provided is the use of a combination of G-CSF or a G-CSF fragment and a DPP IV inhibitor/antagonist in the medical intervention of an ischemic disorder. Accordingly, the uses and methods of the present invention are preferably suitable for the prevention and/or treatment of ischemia. Moreover, the present invention relates to a composition comprising parathyroid hormone (PTH), preferably PTH (1-34), and/or parathyroid hormone-related peptide (PTHrP), preferably PTHrP (1-34), and/or G-CSF or a G-CSF fragment for use as a pharmaceutical composition. In a particular aspect of the invention, a DPP IV antagonist is applied in the uses, methods and/or compositions of the present invention. The DPP IV antagonist/inhibitor is preferably used in combination with G-CSF or a G-CSF fragment. Also the use of PTH alone or PTHrP alone or in combination with a DPP IV antagonist as well as the one of a combination of G-CSF or a G-CSF fragment and a DPP IV inhibitor/antagonist in the herein disclosed medical and pharmaceutical uses and methods is part of this invention.
