A vascular puncture sealing device includes a tube unit and a sealing unit. The tube unit includes an inner tube and an outer tube. The inner tube includes a first compartment therein. The outer tube includes a second compartment therein. The inner tube is slidably received in the second compartment. The sealing unit is coupled to an end of the inner tube. The sealing unit includes an abutting portion and an expansion portion. The abutting portion includes a first face and a second face opposite to the first face. The abutting portion further includes a through-hole extending from the first face through the second face. The expansion portion includes a chamber intercommunicated with the through-hole of the abutting portion.
