ВЕХРИНГ Рейнхард (US),ХАРТМАН Майкл Стивен (US),СМИТ Адриан Эдвард (US),ДЖОШИ Видия Б. (US),ДВИВЕДИ Сарваджна Кумар (US)
申请号：
RU2011152960/15
公开号：
RU2011152960A
申请日:
2010.05.28
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A pharmaceutical composition delivered from a metered-dose inhaler, comprising: a suspension medium containing a pharmaceutically acceptable propellant； a plurality of active substance particles containing an active substance selected from an active substance that is a long acting muscarinic receptor antagonist (LAMA) and an active substance that is a long acting β-adrenergic receptor agonist (LABA)； and a plurality of respirable suspending particles, wherein the plurality of particles of the active substance are associated with the plurality of suspending particles to form a suspension. 2. The pharmaceutical composition according to claim 1, in which the active substance included in the particles of the active substance is an active substance LAMA selected from glycopyrrolate, dexypyrronium, tiotropium, trospium, aklidinium, darotopia and any pharmaceutically acceptable salts, esters, isomers or solvates thereof .3. The pharmaceutical composition of claim 2, wherein the particles of the active substance comprise glycopyrrolate, including any pharmaceutically acceptable salts, esters, isomers or solvates thereof. The pharmaceutical composition according to claim 3, in which the particles of the active substance contain crystalline glycopyrrolate. The pharmaceutical composition according to claim 3, in which the particles of the active substance glycopyrrolate are included in the suspension medium in a concentration sufficient to provide a delivered dose of glycopyrrolate to activate the inhaler with a metered dose selected from from about 2 μg to about 200 μg per actuation, from about 10 mcg to approx1. Фармацевтическая композиция, доставляемая из ингалятора с отмеряемой дозой, содержащая: суспензионную среду, содержащую фармацевтически приемлемый пропеллент； множество частиц активного вещества, содержащих активное вещество, выбранное из активного вещества, представляющего собой антагонист мускариновых рецепторов длительного действия (LAMA), и активного вещества,
