#$%^&*AU2017213518A120170831.pdf#####BIOACTIVE FRACTIONS FROM STRESS-INDUCED PHOTOSYNTHETIC ORGANISMS AND METHODS OF THEIR MANUFACTURE AND USE ABSTRACT The present invention relates to bioactive fractions isolated from stress-induced photosynthetic organisms. The present invention also relates to methods of producing stress-induced photosynthetic organisms suitable for isolating altered bioactive fractions. The present invention further relates to bioactive compositions, bioactive topical formulations, and methods of their use.