With piridilo substituted heteroaryl compounds as kinase modulators； Pharmaceutical composition that comprises； and its use for the treatment of an inflammatory or Autoimmune Disease such as Crohn's disease, multiple sclerosis, systemic lupus erythematosus, and Gout Gouty arthritis.
DUNCIA JOHN V.,GARDNER DANIEL S.,SANTELLA JOSEPH B.,BHIDE RAJEEV S.,HYNES JOHN,NAIR SATHEESH K.,PITTS WILLIAM J.,KUMAR STREEKANTHA R.,MARUGESEN NATESAN,PAIDI VENKATRAM REDDY,SISTLA RAMESH,WU HONG
申请号：
CL2015001249
公开号：
CL2015001249A1
申请日:
2015.05.08
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.COMPUESTOS DERIVADOS DE PIRIDILO SUSTITUIDOS CON HETEROARILO, MODULADORES DE QUINASA； COMPOSICION FARMACEUTICA； Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD INFLAMATORIA O AUTOINMUNE, TAL COMO LA ENFERMEDAD DE CROHN, LUPUS ERITEMATOSO SISTEMICO, ESCLEROSIS MULTIPLE, GOTA Y ARTRITIS GOTOSA.
