Compounds of formula 1:are disclosed, wherein V is CH2； W is S(O)m； m is the integer 0, 1 or 2； U is O, C(O), CR13R14 or NR15； where R13 is H, alkyl； R14 is H, OH, OR13 or OCOR13； R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl； R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitors of tumor necrosis factor-alpha (TNF-α) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF-α activity, in particular inflammations.
