A system for monitoring and evaluating cardiac anomalies of a patient requires a cardiac sensor for detecting cardiac signals, and a perturbation sensor for detecting perturbations caused by stimuli that influence the cardiac signals. Based on normal cardiac signals for the patient, a cardio-profile is created which includes ranges of acceptable variations in selected parameters for the waveform of the cardiac signals. When a perturbation is detected by the perturbation sensor, its influence on the corresponding cardiac signal is evaluated relative to the cardio-profile to determine whether an anomaly has occurred. If so, the perturbation and the cardiac signal are further evaluated to determine whether a medical response is required.