BECK, Hilary Plake,WILLIAMS, David K,MARKWALDER, Jay A,CHERNEY, Emily Charlotte,SHAN, Weifang,HUANG, Audris,JAEN, Juan Carlos,OSIPOV, Maksim,POWERS, Jay Patrick,REILLY, Maureen Kay,SHUNATONA, Hunter P
申请号:
USUS2015/059311
公开号:
WO2016/073770A1
申请日:
2015.11.05
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3- dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.L'invention concerne des composés qui assurent la modulation de l'enzyme oxydo-réductase indoleamine 2,3-dioxygénase, ainsi que des compositions contenant ces composés. L'invention concerne également l'utilisation de tels composés et compositions dans le traitement et/ou la prévention d'un ensemble varié de maladies, troubles et affections, y compris de troubles liés au cancer et à l'immunité, à médiation par l'indoleamine 2,3-dioxygénase.