SOLTIS, DANIEL A.,MEHRLING, THOMAS,BUICK, RICHARD JOHN
申请号:
CA3083345
公开号:
CA3083345A1
申请日:
2018.11.26
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The present disclosure provides humanized antibodies and antibody-drug conjugates that specifically bind to human tissue factor, and which do not inhibit tissue factor mediated blood coagulation compared to a normal plasma control. Further described are methods of making and methods of using the disclosed humanized antibodies and antibody-drug conjugates in the treatment of cancer.