SMITH, Roger A.,DAMLE, Nitin K.,YURKOVETSKIY, Aleksandr V.,YIN, Mao,LOWINGER, Timothy B.,THOMAS, Joshua D.,STEVENSON, Cheri A.,GURIJALA, Venu R.
申请号：
ES14802528
公开号：
ES2754397T3
申请日:
2014.10.10
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
