The present invention relates to isolated nucleic acid molecules which encode an antigen from a nontypable Haemophilus influenzae (H. influenzae) species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a nontypable Haemophilus influenzae species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by nontypable Haemophilus influenzae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with nontypable Haemophilus influenzae and methods for the treatment or prevention of an infection with nontypable Haemophilus influenzae.La présente invention concerne des molécules dacide nucléique isolées codant pour un antigène provenant dune espèce Haemophilus influenzae (H. influenzae) non typable, un vecteur qui comprend de telles molécules dacide nucléique, et une cellule hôte comprenant un tel vecteur. En outre, linvention concerne des antigènes provenant dune espèce Haemophilus influenzae non typable, ainsi que des fragments et des variantes de celle-ci, un procédé de production de tels antigènes, et un procédé de production dune cellule qui exprime un tel antigène. Plus spécifiquement, de tels antigènes sont produits par, ou associés à, des infections bactériennes provoquées par Haemophilus influenza
