L'UTILISATION D'HYDROXYNORKETAMINE, DE DESHYDRONORKETAMINE ET D'AUTRES METABOLITES DE KETAMINE POUR LE TRAITEMENT DE LA DEPRESSION ET DE LA DOULEUR NEUROPATHIQUE
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE COOPER HEALTH SYSTEM;THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES;SRI INTERNATIONAL
发明人:
WAINER, IRVING W.,MOADDEL, RUIN,BERNIER, MICHEL,ZARATE, CARLOS A.,TORJMAN, MARC C.,GOLDBERG, MICHAEL E.,TANGA, MARY J.
申请号：
CA2851619
公开号：
CA2851619A1
申请日:
2012.10.15
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.
