TGF- ß receptor II isoform, fusion peptide, methods of treatment and methods in vitro

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专利权人:

Consejo Nacional de Investigaciones Científcas Y Técnicas (Conicet);Fundación Articular

发明人:

ROMO, Ana,LA COLLA, Anabela Belen,PREISEGGER, Matias Adan,BERTOLIO, Marcela Soledad,DEWEY, Ricardo Alfredo,VELAZQUEZ, Pamela Daiana,CHISARI, Andrea Nancy,RODRIGUEZ, Tania Melina,VELASCO ZAMORA, Benito

申请号：

AU2019240609

公开号：

AU2019240609A1

申请日:

2019.10.02

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2019240609A120200514.pdf#####TGF- p receptor II isoform, fusion peptide, methods of treatment and methods in vitro ABSTRACT An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain. A fusion peptide is provided comprising an isoform of the TGF beta II receptor fused to a ligand, wherein a vector comprising the fusion peptide is used to treat cancer and/or hepatic fibrosis. A method of treating hepatic fibrosis or cancer diseases, comprising the step of administering to a mammal in need thereof a vector bearing a polynucleotide sequence set forth in SEQ ID No. 7.

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