ANDIAPPAN MURUGAN;VASANTHA KRISHNA KADAMBAR;CHANDRASEKHARA REDDY CHINTAKUNTLA;MAURICE RAYMOND VERSCHOY;SAM BUTTERWORTH;CLAUDIO EDMUNDO CHUAQUI;RICHARD ANDREW WARD;ASTRAZENECA AB;HEATHER MARIE REDFEARN
发明人:
ANDIAPPAN MURUGAN,SAM BUTTERWORTH,RICHARD ANDREW WARD,HEATHER MARIE REDFEARN,CLAUDIO EDMUNDO CHUAQUI,VASANTHA KRISHNA KADAMBAR,CHANDRASEKHARA REDDY CHINTAKUNTLA,MAURICE RAYMOND VERSCHOYLE FINLAY
申请号：
IL24227915
公开号：
IL242279A
申请日:
2015.10.26
申请国别(地区):
IL
年份:
2016
代理人:
摘要：
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.
