布魯頓氏酪胺酸激酶抑制劑农业专利-农业专业知识服务系统

发明人:: CHEN, WEI,陈　伟,陳　偉,WANG, LONGCHENG,王　隆祥,YAN, SHUNQI,杨　勳奇,楊　勳奇,LOURY, DAVID J.,罗瑞　大卫Ｊ,羅瑞　大衛Ｊ,JIA, ZHAOZHONG J.,贾　召忠Ｊ,賈　召忠Ｊ,FRYE, LEAH LYNN,弗莱　莉亚　林恩,弗萊　莉亞　林恩,GREENWOOD, JEREMY ROBERT,格林伍德　杰洛米　罗伯特,格林,陈伟,陳偉,王隆祥,杨勳奇,楊勳奇,罗瑞大卫J,羅瑞大衛J,贾召忠J,賈召忠J,弗莱莉亚林恩,弗萊莉亞林恩,格林伍德杰洛米罗伯特

摘要：: Disclosed herein are compounds that inhibit Bruton’s tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.本文揭露的是抑制布魯頓氏酪胺酸激酶(Btk)的化合物。亦描述Btk的不可逆抑制劑。此外，亦描述Btk的可逆抑制劑。亦揭露包括該些化合物之醫藥組成物。所揭露的是使用Btk抑制劑(單獨或與其它治療劑組合)用以治療自體免疫疾病或病狀、異種免疫疾病或病狀、癌症(包括淋巴瘤)、及發炎性疾病或病狀的方法。