A controlled-release composition for topical application to a substrate includes an oil-in-water emulsion and an active agent incorporated into the oil-in-water emulsion. The oil-in-water emulsion is substantially free of lipophilic solvent and is formed by mechanical inversion of a water-in-oil emulsion. The water-in-oil emulsion includes a silicone component, a surfactant, and water. A method of delivering the active agent to the substrate provides the oil-in-water emulsion and incorporates the active agent into the oil-in-water emulsion for delivery of the active agent to the substrate upon application of the oil-in-water emulsion to the substrate.기재에 국소 적용하기 위한 다층 드레싱 및 방출 제어 조성물은 에멀젼과 이 에멀젼 내로 혼입되는 활성제를 포함한다. 상기 활성제는 단백질을 포함한다. 상기 활성제를 기재로 전달하는 방법은, 에멀젼을 제공하고 상기 활성제를 상기 에멀젼 내로 혼입시켜 상기 활성제를 기재로 전달하는 것이다.
