A UVC disinfection system which produces a dosage of UVC radiation sufficient to kill Clostridium difficile and other pathogens in a simple fast and unique manner. The system is especially useful for sterilizing and disinfecting medical ultrasound probes or transducers. The system in one embodiment comprises an enclosure for housing a plurality of UVC lamps which are disposed around a central area in which an ultrasound transducer can be disposed. The lamps are disposed in a vertical orientation, as is the transducer and provide 360° of UVC radiation around the transducer for effective and efficient decontamination. The UVC lamps can also be provided at the bottom of the enclosure. The system is controlled by an electronic controller which typically is a microprocessor based controller for control of the ballasts for the UVC lamps and having associated control switches and displays. The current input to the ballasts is monitored by the controller to assure that the UVC lamps are operating properly. A UVC radiation sensor provided in the housing monitors radiation intensity from the lamps. If the current and/or radiation intensity is below reference levels, the system is shut down by the controller.