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Dolastatin 15 derivatives
专利权人:
Andreas Kling;Andreas Haupt;Thomas Zierke;Bernd Janssen;Teresa Barlozzari
发明人:
Bernd Janssen,Teresa Barlozzari,Andreas Haupt,Thomas Zierke,Andreas Kling
申请号:
US12648446
公开号:
US08163698B2
申请日:
2009.12.29
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Compounds of the present invention include cell growth inhibitors which are peptides of Formula I,A-B-D-E-F-(G)r-(K)s-L  (I),and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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