ROMBOUTS, FREDERIK JAN RITA,LOVE, CHRISTOPHER JOHN,VAN EMELEN, KRISTOF,VAN BRANDT, SVEN FRANCISCUS ANNA,WU, TONGFEI
申请号：
CA2611438
公开号：
CA2611438C
申请日:
2006.06.26
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention concerns the compounds of formula (I), the N-oxideforms, the pharmaceutically acceptable addition salts and the stereochemicallyisomeric forms thereof, wherein m represents 1, n represents 1, Z represents Nor C, in particular N； -X1- represents C1-4alkyl, in particular methyl； -X2-represents -C1-4alkyl- or -C1-4alkyl-NR7-, in particular propyl, -ethyl-NR7-or -propyl-NR7-； -Y- represents-NR2-C1-6alkyl-CO-NR4-, -Het1-C1-6alkyl-CO-NR5-or -Het2-CO-NR6- and wherein the -C1-6alkyl- linker of -NR2-C1-6alkyl-CO-NR4-or -Het1-C1-6alkyl-CO-NR5- is optionally substituted with one or wherepossible two or more substituents selected from hydroxy, halo and phenyl； R1represents hydrogen, chloro, fluoro or bromo； R2 represents -C1-4alkyl-, inparticular ethyl or methyl； R7 represents hydrogen； R8 represents hydrogen；R4, R5 and R6 represent hydrogen； Het1 is selected from piperazinyl orpiperidinyl, in particular -piperazinyl； Het2 selected from pyrrolidinyl orpiperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl isoptionally substituted with hydroxy.
