HMGB1的A盒和HMGB1的A盒變體的聚合體綴合物

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专利权人:

CREABILIS THERAPEUTICS S.P.A.

发明人:

SILVIO TRAVERSA,CHIARA LORENZETTO,VALENTINA MAINERO,SEBASTIANO MORENA,SILVANO FUMERO,LUCA BECCARIA

申请号：

HK09111955.1

公开号：

HK1134779B

申请日:

2009.12.18

申请国别(地区):

HK

年份:

2013

代理人:

摘要：

The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.

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中国工程科技知识中心

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http://www.ckcest.cn/home/