The present invention relates to a method for treating a cancer with the combination of a topoisomerase II inhibitor (TOP2 inhibitor) and a histone deacetylation inhibitor (HDACi), provides synergistic cancer cell-killing effects, and prolonged overall survival, especially when the expression of checkpoint kinase 1 (CHK-1) is low.本發明關於一種以拓樸異構酶II抑制劑(TOP2抑制劑)及組蛋白去乙醯化抑制劑 (HDACi)的組合治療癌症的方法,特別是當細胞週期檢測點激酶1(CHK-1)的表現量低時,提供協同的癌細胞殺傷功效,以及延長的整體存活期。
