The ozone cleaning device contains an electrically conductive member and a reinforced casing member. The casing member is injection-molded and houses the conductive member inside in an airtight manner. The reinforcement of the casing member, and the tight integration between the casing member and the conductive member jointly achieve enhanced structural strength to prevent the ozone cleaning device from being broken. When the ozone cleaning device is held close to a user and an electrical power is delivered to the conductive member, the conductive member is then conducting to the user and the air in between is influenced by the electrical power to produce ozone for cleaning. The present invention therefore achieves enhanced structural strength, usage safety, and prolonged operational life.