RÉACTIF ET PROCÉDÉ DE DÉSOXYFLUORATION SPÉCIFIQUE AU SITE DE PEPTIDES

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专利权人:

Studiengesellschaft Kohle MbH

发明人:

申请号：

EP18181390.8

公开号：

EP3590911A1

申请日:

2018.07.03

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The present invention refers to reagents and methods for preparing a peptide sequence having a [18F]fluoro-aromatic amino acid side which may be further substituted, in particular a 4-[18F]fluoro-phenylalanine side chain in peptide sequences, by chemoselective radio-deoxyfluorination of an aromatic amino acid residue, in particular a tyrosine residue using a traceless-activating group and the reagents used in said process.

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