The present invention concerns antibody-like binding protein specifically binding to CD3 and CD123. The invention also relates to pharmaceutical compositions comprising said antibody-like binding protein and the use of said pharmaceutical compositions and antibody-like binding protein to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein.本發明涉及特異性結合至CD3和CD123的抗體樣結合蛋白。本發明還涉及包含所述抗體樣結合蛋白的醫藥組合物及所述醫藥組合物和抗體樣結合蛋白用於治療癌症的用途。本發明進一步涉及包含編碼所述抗體樣結合蛋白的序列的分離的核酸、載體和宿主細胞。