In the manufacture of medicaments for use, or benzodiazepines of formula (I), [wherein the use of a pharmaceutically acceptable salt thereof to the preventing or treating hepatitis C infection: -R 1 is, C 1 represents hydrogen or C 1-6 alkyl -R 2 is represents heteroaryl -6 alkyl, or aryl, - and R 3 each, it is the same or different halogen, hydroxy, C 1-6 alkyl , C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 haloalkyl, C 1-6 haloalkoxy, amino, mono (C 1-6 alkyl) amino, di (C 1-6 alkyl) amino, nitro, cyano, -CO 2 R , - CONRR ", - NH-CO-R, - S (O) R , - S (O) 2 R, - NH-S (O) 2 R , -S (O) NRR ", or (O) 2 NRR -S" represents, R and R "each, are the same or different, a hydrogen or C 1-6 alkyl here The -n, there are 0-3 represents -R 4 represents hydrogen or C 1-6 alkyl are -R 5, C 1-6 alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl - ( C 1-6 alkyl) -, heteroaryl - (C 1-6 alkyl) -, carbocyclyl - (C 1-6 alkyl) -, heterocyclyl - (C 1-6 alkyl) -, aryl - (C 1-6 hydroxy alkyl) -, heteroaryl - (C 1-6 hydroxyalkyl) -, carbocyclyl - (C 1-6 hydroxyalkyl) -, heterocyclyl - (C 1-6 hydroxyalkyl) -, aryl--C (O) -C ( O) -, heteroaryl -C (O) -C (O) -, carbocyclyl -C (O) -C (O) -, heterocyclyl -C (O) -C (O) -, or represents a -XR 6 -X is, -CO - or, (O) 2 -S - -, - S (O) represents are -R 6, C 1-6 alkyl, hydroxy, C 1-6 alkoxy, C 1 and 6 alkylthio, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl - (C 1-6 alkyl) -, heteroaryl - (C 1-6 alkyl) -, carbocyclyl - (C 1-6 alkyl) -, heterocyclyl - (C 1-6 alkyl) -, aryl - (C 1-6 alkyl) -O-, heteroaryl - (C 1-6 alkyl) -O-, carbocyclyl - (C 1-6 alkyl) -O-, heterocyclyl - ( C 1-6 alkyl) -O-, or "represent, R and R each here" -NRR is, it is the same or different, hydrogen, C 1-6 alkyl, carbocyclyl, heterocyclyl, aryl , heteroaryl, aryl - (C 1-6 alkyl) -, heteroaryl - (C 1-6 alkyl) -, carbocyclyl - (C 1-6 alkyl) -, heterocyclyl or - a - (C 1-6 alkyl) represent].C型肝炎感染症を治療するか又は予防することに使用の医薬品の製造における、式(I)のベンゾジアゼピン、又はその医薬的に許容される塩の使用[式中:-R1は、C1-6アルキル、アリール、
