BILE SALT HYDROLASE BSH1 FOR REGULATING WEIGHT GAIN, SERUM CHOLESTEROL LEVELS, AND LIVER TRIGLYCERIDES IN A MAMMAL； BACTERIA STRAINS EXPRESSING BSH1 VARIANTS
UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY OF IRELAND; CORK
发明人:
Susan Joyce,Cormac Gahan,Colin Hill
申请号：
US14897484
公开号：
US20160120963A1
申请日:
2014.06.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A non-therapeutic method of reducing weight gain, serum cholesterol levels, or liver triglyceride levels, in a non-obese mammal, comprises the step of administering to the gut of a mammal an effective amount of a bacteria expressing a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof； a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof for use as a medicament； isolated bacterial strains expressing functional variants of BSH1.
