MADERNA ANDREAS,SUBRAMANYAM CHAKRAPANI,TUMEY LAWRENCE N,CHEN ZECHENG,CASAVANT JEFFREY M
申请号：
IN201717030394
公开号：
IN201717030394A
申请日:
2017.08.28
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention is directed to novel bifunctional CTI CTI and CBI CTI dimers of the formula: F L T L F where F L T L and F are as defined herein useful for the treatment for proliferative diseases where the inventive dimers can function as stand alone drugs payloads in antibody drug conjugates (ADCs) and linker payload compounds useful in connection with the production or administration of such ADCs； and to compositions including the aforementioned dimers linker payloads and ADCs and methods for using these dimers linker payloads and ADCs to treat pathological conditions including cancer.
