Provided herein are compounds and compositions useful in increasing PPARd activity. The compounds and compositions provided herein are useful for the treatment of PPARd related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).本發明提供適用於提高PPARd活性之化合物及組合物。本文所提供之該等化合物及組合物適用於治療PPARd相關之疾病(例如,肌肉疾病、血管疾病、髓鞘脫失病及代謝疾病)。