オキシコドン経皮吸収医薬組成物、医薬組成物貯蔵ユニットおよびこれを利用する経皮吸収製剤

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专利权人:

テイカ製薬株式会社

发明人:

木村 隆仁,折橋 正浩,藤下 繁人,高畠 浩一,加藤 達久,塩田 聡,島 雄一郎

申请号：

JP2008219877

公开号：

JP5345813B2

申请日:

2008.08.28

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a percutaneously absorbable pharmaceutical composition maintaining the blood concentration of oxycodone in an effective level over at least 48 hr on applying to a human.

SOLUTION: The percutaneously absorbable pharmaceutical composition prepared by blending an active ingredient selected from the oxycodone or its salts in an active ingredient-holding medium having fluidity at a temperature in the vicinity of a human skin surface temperature by a blending amount higher than its saturation solubility and holding at least a part of the active ingredient as a crystal form is characterized by making the preparation so that the percutaneously absorbable pharmaceutical composition has 31.1 mg content of the active ingredient based on the oxycodone base per one sheet and an effective percutaneous absorption range becomes as a square having 1.5 cm side, and showing at least &ge150 &mug/hr/cm2mean permeation rate of the active ingredient based on the oxycodone base on applying it on the abdominal flawless skin of a hairless rat for 48 h.

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来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/