A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood； a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system； an oxygen source including a pressure regulator configured to regulate an oxygen pressure； an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood； a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure； a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator； and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.
