PROBLEM TO BE SOLVED: To provide a compound exhibiting inhibitory action on AMPA receptor and/or kainate receptor as a therapeutic/prophylactic/improving agent for various nerve diseases by suppressing the neurotoxicity of excitatory neurotransmitters and achieving neuroprotecting action.SOLUTION: The present invention provides a compound represented by formula (I) a salt thereof or a hydrate of them. In formula (I), A1, A2 and A3 are each a 3-8C cycloalkyl group, a 3-8C cycloalkenyl group, a 5 to 14C membered nonaromatic heterocyclic group, a 6-14C aromatic hydrocarbon cyclic group or a 5-14C membered aromatic heterocyclic group Q is O, S or NH Z is C or N X1, X2 and X3 are each a single bond, a 1-6C alkylene group or the like R1 and R2 are each a hydrogen atom, a 1-6C alkyl group or the like R3 is a hydrogen atom, a 1-6C alkyl group or the like.COPYRIGHT: (C)2009,JPO&INPIT【課題】興奮性神経伝達物質の神経毒性を抑制し、且つ、神経保護作用を発揮して、各種神経疾患の治療・予防・改善剤としてのAMPA受容体および/またはカイニン酸受容体阻害化合物の提供。【解決手段】式(I)で表わされる化合物もしくはその塩またはそれらの水和物。〔式中、A1、A2およびA3はC3-8シクロアルキル基、C3-8シクロアルケニル基、5乃至14員非芳香族複素環式基、C6-14芳香族炭化水素環式基または5乃至14員芳香族複素環式基、QはO、SまたはNH、ZはCまたはN、X1、X2およびX3は単結合、C1-6アルキレン基等、R1およびR2は水素原子、C1-6アルキル基等、R3は水素原子、C1-6アルキル基等を示す。〕【選択図】なし
