THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
发明人:
GUERRY, PATRICIA,JIAO, YUENING,MONTEIRO, MARIO ARTUR,PEQUEGNAT, BRITTANY MICHELE
申请号：
CA3004305
公开号：
CA3004305A1
申请日:
2016.11.03
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention relates toimmunogenic synthetic constructs capable ofinducing an immune response againstCampylobacter jejuni (C. jejuni) in a subjectcomprising one or more monosaccharidescomprising one or more MeOPN moieties.Specifically, the invention relates to immunogenicsynthetic constructs capable of inducing animmune response against C. jejuni in a subjectcomprising one or more MeOPN-6-Galmonosaccharides, one or more MeQPN-4-Galmonosaccharides, and/or one or moreMeOPN-2-Gal monosaccharides. Theinvention also relates to compositions comprisingthe immunogenic synthetic constructs, andmethods of inducing an immune responseagainst C. jejuni in a subject comprisingadministering the immunogenic syntheticconstructs, and/or compositions comprising theimmunogenic synthetic constructs, to thesubject. Methods of treating, preventing, orameliorating a C. jejuni bacterial infection in asubject comprising administering to the subjectone or more doses of immunoglobulinsdirected to one or more of the MeOPN moieties arealso contemplated.
