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Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug
专利权人:
Thomas E. Jenkins
发明人:
Thomas E. Jenkins,Craig O. Husfeld
申请号:
US13346281
公开号:
US20120178773A1
申请日:
2012.01.09
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The embodiments provide Compound KC-7, N-1-[(S)-2-(oxycodone-6-enol-carbonyl-methyl-amino)-2-carbonyl-sarcosine-ethyl amine]-arginine-glycine-acetate, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the \compositions comprise a prodrug, Compound KC-7, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
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