A method for removing diseased tissue from a tubular organ includes receiving a distal end portion of a tubular body of a surgical stapling device within a tubular organ of a patient. The method further includes retracting a diseased section of tissue of the tubular organ within a lumen of the tubular body. Proximal and distal margin lines of the tubular organ are then positioned adjacent a cylindrical anvil member disposed on the distal end portion of the tubular body. A cartridge assembly is then received within the tubular body in alignment with the anvil member such that sections of healthy tissue are disposed between the cartridge assembly and the anvil assembly. A plurality of staples is then ejected radially outward from within the cartridge assembly through the sections of healthy tissue disposed between the cartridge assembly and the anvil member, and into the anvil member. The diseased tissue is removed through the tubular body of the surgical stapling device.