Pharmaceutical composition comprising a prolonged release of trimetazidine trimetazidine and internal Phase comprising an outer layer comprising a flame retardant and an anti agglomerant； Manufacture process, useful for the prophylactic Treatment of angina pectoris, conditions co Rioretinianas, among other diseases.
Composition for prolonged release of trimetazidine, comprises an inner phase comprising trimetazidine and an outer layer comprising a retardant and an antiagglomerant. An independent claim is included for preparing the composition comprising coating the neutral cores with trimetazidine and the binder to form minigranules, coating the minigranules with the retardant, the plasticizer and the antiagglomerant, and filling the coated minigranules into capsules, optionally in the presence of a lubricant. ACTIVITY : Antianginal； Ophthalmological； Auditory. MECHANISM OF ACTION : None given.COMPOSICION FARMACEUTICA DE LIBERACION PROLONGADA DE TRIMETAZIDINA COMPUESTA POR UNA FASE INTERNA QUE COMPRENDE A TRIMETAZIDINA Y UNA CAPA EXTERNA QUE COMPRENDE UN RETARDANTE Y UN ANTI-AGLOMERANTE； SU PROCESO DE FABRICACION, UTIL PARA EL TRATAMIENTO PROFILACTICO DE LA ANGINA DE PECHO, AFECCIONES CORIORETINIANAS, ENTRE OTRAS ENFERMEDADES.
