METHODS OF IDENTIFYING PATIENTS LIKELY TO BENEFIT FROM TREATMENT WITH A TELOMERASE INHIBITOR

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专利权人:

Geron Corporation

发明人:

Jacqueline Cirillo BUSSOLARI,Fei HUANG

申请号：

US16525026

公开号：

US20200063214A1

申请日:

2019.07.29

申请国别(地区):

US

年份:

2020

代理人:

摘要：

This disclosure provides methods of identifying or selecting a patient most likely to benefit from treatment with a telomerase inhibitor, such as e.g. imetelstat, by testing a patient for: a lack of a mutation in each of JAK2, CALR, and MPL； and/or a high-molecular risk (HMR), based on the presence of a mutation in at least one of the following genes: ASXL1, EZH2, SRSF2, and IDH1/2. The patient may be suffering from myelofibrosis. The disclosure also provides methods of treating myelofibrosis, which include identifying such patients.

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