fusion protein. nucleic acid molecule, vector, genetically modified cell, method of making fusion protein, uses of fusion protein, composition, method of making a composition, kits, method and use of fusion protein
JIANYANG ZHAO,JIURU SUN,JOE ZHOU,JUN LIN,JUN WANG,SHAOXIONG WANG,XINXING MA
申请号：
BRPI1006368
公开号：
BRPI1006368A2
申请日:
2010.03.18
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.
