OXFORD UNIVERSITY INNOVATION LIMITED;YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人:
Simon J. Draper,Ivan Campeotto,Matthew K. Higgins,Sarel Fleishman,Adi Goldenzweig
申请号：
US16331863
公开号：
US20190374629A1
申请日:
2017.09.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising Reticulocyte-binding protein Homologue 5 (PfRH5) antigens. In particular, the invention provides modified PfRH5 antigens rationally designed to produce improved stability and expression profiles whilst maintaining immunogenicity.
